Nicotinamide (Vitamin B3)

A water-soluble vitamin essential for energy metabolism, DNA repair, and skin health.

What is Nicotinamide?

Nicotinamide, also known as niacinamide, is the amide form of Vitamin B3. It plays a crucial role in cellular energy production and skin barrier maintenance.

Unlike niacin, it does not cause flushing.

History & Background

Vitamin B3 was identified during studies on pellagra, a disease caused by niacin deficiency.

Chemical Structure & Properties

• IUPAC name: Pyridine-3-carboxamide
• Molecular formula: C₆H₆N₂O
• Molar mass: 122.12 g/mol
• Nature: Water-soluble amide

Mechanism of Action

Nicotinamide functions by:

• Forming NAD⁺ and NADP⁺ coenzymes
• Supporting cellular respiration
• Aiding DNA repair mechanisms

Health Benefits & Uses

• Energy metabolism support
• Prevention of pellagra
• Skin barrier repair
• Reduction of acne and inflammation

Dosage Guidelines

Adults: 14–16 mg/day

Upper limit: 35 mg/day

⚠️ High doses may cause liver toxicity.

Vitamin B3 Deficiency

• Pellagra
• Dermatitis
• Diarrhea
• Dementia

Side Effects

• Nausea (high doses)
• Headache
• Rare liver effects

Frequently Asked Questions

Is nicotinamide same as niacin? – Related but different.

Does it cause flushing? – No.

Is it good for skin? – Yes.

Is it water-soluble? – Yes.

⚠️ Educational content only. Not a substitute for professional medical advice.