Silver Sulfadiazine

A topical antimicrobial cream widely used to prevent and treat infections in burn wounds.

What is Silver Sulfadiazine?

Silver sulfadiazine is a topical antimicrobial agent primarily used in the management of second- and third-degree burns.

It combines the antibacterial action of silver ions with a sulfonamide antibiotic.

History & Background

Silver sulfadiazine became a standard burn treatment in the 1960s due to its broad antimicrobial spectrum and ability to reduce burn-related infections.

Chemical Structure & Properties

• Chemical name: Silver sulfadiazine
• Molecular formula: C₁₀H₉AgN₄O₂S
• Molar mass: ~357.14 g/mol
• Nature: Poorly water soluble, topical use only

Mechanism of Action

Silver sulfadiazine works by:

• Releasing silver ions that damage bacterial cell walls
• Inhibiting microbial DNA replication
• Providing broad-spectrum antibacterial and antifungal action

Medical Uses

• Prevention of infection in burn wounds
• Treatment of second- and third-degree burns
• Infected skin ulcers (selected cases)

How to Use

Apply a thin layer to the cleaned burn area once or twice daily. Cover with sterile dressing as advised by a healthcare professional.

Side Effects

• Burning or itching at application site
• Skin discoloration
• Delayed wound healing (rare)

Warnings & Precautions

• Avoid use in newborns and premature infants
• Contraindicated in sulfonamide allergy
• Use cautiously in extensive burns

Frequently Asked Questions

Is silver sulfadiazine an antibiotic? – Topical antimicrobial.

Is it used for burns? – Yes.

Can it be used daily? – Yes, as prescribed.

Does it prevent infection? – Yes.

⚠️ Educational content only. Not a substitute for professional medical advice.