Neomycin

A topical aminoglycoside antibiotic used to prevent bacterial infection in minor wounds.

What is Neomycin?

Neomycin is an aminoglycoside antibiotic commonly used in topical formulations to prevent or treat minor skin infections.

It is often combined with other antibiotics in ointments.

History & Background

Neomycin was discovered in the 1940s and became widely used for topical applications due to its effectiveness against Gram-negative bacteria.

Chemical Structure & Properties

• Class: Aminoglycoside antibiotic
• Molecular formula: C₂₃H₄₆N₆O₁₃
• Molar mass: ~614.6 g/mol
• Nature: Highly polar, poorly absorbed orally

Mechanism of Action

Neomycin works by:

• Binding to the 30S ribosomal subunit
• Inhibiting bacterial protein synthesis
• Causing bacterial cell death

Medical Uses

• Minor cuts and wounds
• Prevention of skin infections
• External ear infections (topical)
• Combination antibiotic ointments

Dosage & Application

Apply a thin layer to the affected area 2–3 times daily. Do not use on large or deep wounds.

Side Effects

• Skin irritation
• Contact dermatitis
• Allergic reactions (common)

Warnings & Precautions

• High risk of contact allergy
• Avoid prolonged use
• Do not use on large areas of skin

Frequently Asked Questions

Is neomycin an antibiotic? – Yes.

Why is allergy common? – Skin sensitization.

Is it safe for children? – Short-term use only.

Can it be used daily? – Short duration recommended.

⚠️ Educational content only. Not a substitute for professional medical advice.