Mupirocin

A topical antibiotic used to treat bacterial skin infections like impetigo.

What is Mupirocin?

Mupirocin is a topical antibiotic effective mainly against Gram-positive bacteria, including Staphylococcus aureus.

It is commonly prescribed for localized skin infections.

History & Background

Mupirocin was derived from Pseudomonas fluorescens and introduced to clinical practice for treating resistant skin infections.

Chemical Structure & Properties

• Chemical name: Pseudomonic acid A
• Molecular formula: C₂₆H₄₄O₉
• Molar mass: 500.62 g/mol
• Nature: Fatty acid derivative

Mechanism of Action

Mupirocin works by:

• Inhibiting bacterial isoleucyl-tRNA synthetase
• Blocking protein synthesis
• Preventing bacterial growth and replication

Medical Uses

• Impetigo
• Minor skin infections
• Infected cuts and abrasions
• Nasal decolonization of MRSA

Dosage & Application

Apply a small amount to the affected area 2–3 times daily for up to 10 days or as prescribed.

Side Effects

• Burning or stinging sensation
• Itching or redness
• Rare allergic reactions

Warnings & Precautions

• For topical use only
• Avoid prolonged use
• Discontinue if irritation occurs

Frequently Asked Questions

Is mupirocin an antibiotic? – Yes.

Is it effective against MRSA? – Yes.

Can it be used on face? – With medical advice.

Is it safe for children? – Yes, as prescribed.

⚠️ Educational content only. Not a substitute for professional medical advice.