Clotrimazole

A broad-spectrum antifungal medicine used to treat common fungal skin infections.

What is Clotrimazole?

Clotrimazole is an imidazole antifungal agent used to treat dermatophyte and yeast infections of the skin.

It is effective against Candida, Trichophyton, and Microsporum species.

History & Background

Clotrimazole was introduced in the late 1960s and became one of the most commonly used topical antifungal medicines worldwide.

Chemical Structure & Properties

• IUPAC name: 1-[(2-chlorophenyl)(diphenyl)methyl]-1H-imidazole
• Molecular formula: C₂₂H₁₇ClN₂
• Molar mass: 344.84 g/mol
• Functional groups: Imidazole ring, aromatic rings

Mechanism of Action

Clotrimazole works by:

• Inhibiting fungal ergosterol synthesis
• Disrupting fungal cell membrane integrity
• Causing leakage of cellular contents

Medical Uses

• Ringworm (tinea corporis)
• Athlete’s foot (tinea pedis)
• Jock itch (tinea cruris)
• Candidal skin infections

Dosage & Application

Apply a thin layer to the affected area 2–3 times daily for 2–4 weeks or as advised by a doctor.

Side Effects

• Mild burning or irritation
• Redness
• Itching

Warnings & Precautions

• For external use only
• Avoid contact with eyes
• Complete full course of treatment

Frequently Asked Questions

Is clotrimazole an antibiotic? – No, it is an antifungal.

Can it be used on face? – With medical advice.

Is it safe for children? – Yes.

How long to use? – 2–4 weeks.

⚠️ Educational content only. Not a substitute for professional medical advice.