Bacitracin

A topical polypeptide antibiotic used to prevent bacterial infection in minor skin injuries.

What is Bacitracin?

Bacitracin is a polypeptide antibiotic used primarily in topical preparations to prevent infection in minor cuts, scrapes, and burns.

It is commonly found in combination antibiotic ointments.

History & Background

Bacitracin was discovered in the 1940s and named after the patient from whom the producing organism was isolated.

Chemical Structure & Properties

• Class: Polypeptide antibiotic
• Source: Bacillus species
• Nature: Peptide mixture (Bacitracin A most active)
• Solubility: Water soluble (limited)

Mechanism of Action

Bacitracin works by:

• Inhibiting bacterial cell wall synthesis
• Blocking dephosphorylation of lipid carriers
• Preventing peptidoglycan formation

Medical Uses

• Minor cuts and abrasions
• Prevention of skin infections
• Post-surgical wound care
• Combination topical antibiotic products

Dosage & Application

Apply a thin layer to the affected area 1–3 times daily. Cover with a sterile bandage if needed.

Side Effects

• Skin irritation
• Contact dermatitis
• Rare allergic reactions

Warnings & Precautions

• For topical use only
• Avoid prolonged use
• Do not apply on large areas

Frequently Asked Questions

Is bacitracin an antibiotic? – Yes.

Is it safe for wounds? – Yes, minor wounds.

Can it cause allergy? – Rarely.

Is it better than neomycin? – Lower allergy risk.

⚠️ Educational content only. Not a substitute for professional medical advice.