Aceclofenac

A modern anti-inflammatory painkiller known for strong efficacy with improved gastric tolerance.

What is Aceclofenac?

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation, particularly in musculoskeletal and joint disorders. It is chemically related to diclofenac but is designed to offer better gastrointestinal tolerability.

Because of this balance between efficacy and safety, aceclofenac is widely prescribed for chronic inflammatory conditions.

History & Development

Aceclofenac was developed as a derivative of diclofenac to retain strong anti-inflammatory action while reducing gastric side effects. It gained popularity in the 1990s, especially in orthopedic and rheumatology practice.

Chemical Structure & Properties

• IUPAC name: 2-[2-[2,6-dichloroanilino]phenyl]acetoxyacetic acid
• Molecular formula: C₁₆H₁₃Cl₂NO₄
• Molar mass: 354.18 g/mol
• Functional groups: Ester, carboxylic acid, aromatic rings

Aceclofenac contains an ester linkage that modifies its pharmacological behavior and contributes to improved gastric safety compared to diclofenac.

Mechanism of Action

Aceclofenac inhibits cyclooxygenase enzymes (COX-1 and COX-2), with greater selectivity toward COX-2. This results in:

• Reduced prostaglandin synthesis
• Decreased inflammation and swelling
• Effective pain relief

Lower COX-1 inhibition explains its relatively lower gastric toxicity.

Pharmacokinetics

• Absorption: Rapid after oral administration
• Peak plasma time: 1.5–3 hours
• Protein binding: >99%
• Metabolism: Liver (to diclofenac and other metabolites)
• Excretion: Mainly urine

Medical Uses

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Back pain and neck pain
• Post-traumatic and post-surgical pain

Dosage Guidelines

Adults: 100 mg twice daily

Maximum daily dose: 200 mg

⚠️ Take after food to minimize gastric irritation.

Side Effects

• Indigestion
• Abdominal discomfort
• Nausea
• Dizziness

Serious Risks & Warnings

• Gastric ulcers (rare but possible)
• Liver enzyme elevation
• Kidney impairment (long-term use)
• Cardiovascular risk in predisposed patients

Drug Interactions

• Other NSAIDs
• Blood thinners
• Antihypertensive drugs
• Alcohol

Aceclofenac vs Diclofenac

Aceclofenac offers similar pain relief with better stomach tolerance, while diclofenac may act faster but has higher gastric risk.

Frequently Asked Questions

Is aceclofenac stronger than diclofenac? – Potency is similar, tolerance differs.

Can it be used long-term? – Only under medical supervision.

Is aceclofenac an antibiotic? – No.

Does it reduce swelling? – Yes.

⚠️ Educational content only. Not a substitute for professional medical advice.