Cefixime

A third-generation cephalosporin antibiotic used for common bacterial infections.

What is Cefixime?

Cefixime is a third-generation cephalosporin antibiotic effective against a wide range of Gram-positive and Gram-negative bacteria.

It is commonly prescribed for respiratory and urinary tract infections.

History & Background

Cefixime was developed to provide strong oral cephalosporin activity with improved resistance to beta-lactamases.

Chemical Structure & Properties

• IUPAC name: (6R,7R)-7-[(2Z)-2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• Molecular formula: C₁₆H₁₅N₅O₇S₂
• Molar mass: 453.45 g/mol
• Functional groups: Beta-lactam ring, thiazole

Mechanism of Action

Cefixime kills bacteria by:

• Inhibiting bacterial cell wall synthesis
• Binding to penicillin-binding proteins
• Causing bacterial cell lysis

Pharmacokinetics

• Absorption: Moderate oral absorption
• Peak plasma time: 2–4 hours
• Half-life: 3–4 hours
• Metabolism: Minimal
• Excretion: Urine and bile

Medical Uses

• Respiratory tract infections
• Urinary tract infections
• Typhoid fever
• Otitis media

Dosage Guidelines

Adults: 200–400 mg once daily or in divided doses

Children: Weight-based dosing

⚠️ Complete the full antibiotic course.

Side Effects

• Diarrhea
• Nausea
• Abdominal pain
• Skin rash

Warnings & Precautions

• Use cautiously in penicillin allergy
• Risk of antibiotic resistance
• Adjust dose in kidney disease

Drug Interactions

• Anticoagulants
• Carbamazepine

Frequently Asked Questions

Is cefixime strong? – Yes, third-generation cephalosporin.

Is it safe for children? – Yes, with proper dosing.

Does it treat viral infections? – No.

Can it be taken with food? – Yes.

⚠️ Educational content only. Not a substitute for professional medical advice.